The Crime Syndicate of America is the evil counterpart of the Justice League on Earth-Three, where they rule the universe with an iron fist.
The Crime Syndicate of America debuted in Justice League of America #29 (August 1964). An alternative team, the Crime Syndicate of Amerika debuted in JLA: Earth 2 (September 2000).
In this universe, Alexander Luthor, Jr. was a hero who wished to rid his world of Ultraman.
In the New 52, they debuted in Justice League (vol. 2) #23 (October 2013)