Argent used to have a complex relationship with Scott, as he immensely disliked him because the latter was dating his daughter, Allison. It only worsened after learning Scott was a teenage werewolf. Despite his rivalry with Scott, Chris had no intention of killing him because of the hunters' Codes against harming children or innocent werewolves who never spilled innocent blood. Ultimately, the two had to set aside their differences when they were against a common threat in Gerard and Peter. However, after Allison's death, Argent continued to help Scott's pack to honor his daughter's memory. After leaving in Season 3, he returned to save Scott from his deranged sister.
By the end of season 6, Chris became more helpful to Scott, showing concern for his safety when he wanted Scott and the kids to leave Beacon Hills to survive. When that didn't work, Chris decided to help Scott and brought reinforcements to their cause including Derek Hale. In the two-year flashforward, Argent continued to help Scott track down the werewolf boy, Alec and reaffirmed his trust to a person he never thought he could and someone who saved his life more than once.
Later, Chris protected Stiles and Scott's body (which was trapped in a coma in order to lure out the Benefactor) and this time, Chris didn't hesitate to pull the gun on her yet again. He lost all hope of his younger sister finding redemption because she tried to have Scott killed by turning him into a berserker and unrightfully blamed Allison's death on her pack. He ended up shooting her with a yellow wolfsbane bullet and joined the Calavera family to both protect the McCall Pack and hunt his sister.